Table 9.
Pharmacokinetic Parameters for QLS-101 and Levcromakalim in Beagle Dogs Following Intravenous Dosing with QLS-101
| Pharmacokinetic Parameters | 0.05 mg/kg |
0.5 mg/kg |
1.5 mg/kg |
3 mg/kg |
5 mg/kg |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| M | F | M | F | M | F | M | F | M | F | |
| QLS-101 | ||||||||||
| Cmax (ng/mL) | 245 | 356 | 2,600 | 2,990 | 7,690 | 9,050 | 14,400 | 18,400 | 22,400 | 29,300 |
| AUC0–24h (ng·h/mL) | 1,120 | 2,100 | 14,300 | 20,900 | 43,200 | 61,200 | 85,100 | 128,000 | 159,000 | 311,000 |
| Tmax (h) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| T1/2 (h) | 2.23 | 3.26 | 2.84 | 4.11 | 2.91 | 4.68 | 6.22 | 2.94 | 3.47 | 5.98 |
| Levcromakalim | ||||||||||
| Cmax (ng/mL) | 0.826 | NR | 7.3 | 5.13 | 18 | 15.6 | 42.7 | 28.3 | 65.8 | 82.7 |
| AUC0–24h (ng·h/mL) | 5.04 | NR | 45.5 | 81.3 | 183 | 241 | 476 | 386 | 741 | 1,040 |
| Tmax (h) | 1 | NR | 1 | 3 | 1 | 3 | 1 | 6 | 1 | 3 |
| T1/2 (h) | 9.66 | NR | 6.89 | 10.3 | 5.27 | 7.58 | 6.48 | 5.07 | 7.67 | 7.82 |
NR, not reported.