Figure 3.

Enhanced classification accuracy using tumor-specific CSF methylomes. (A) Ensemble of ROC curves for 50 iterations of one-class versus others classifiers trained using tumor-specific features (present in both tissue and CSF discovery set comparisons), showing enhanced accuracy in classifying tumor types within CSF validation set samples in comparison to Figure 1C. (B) Distribution of validation set probabilities for representative clinical cases of malignant brain tumors that cannot be reliably distinguished using standard-of-care MRI, but are accurately classified using CSF methylomes.