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. Author manuscript; available in PMC: 2023 Aug 3.
Published in final edited form as: Annu Rev Biochem. 2023 Mar 31;92:247–272. doi: 10.1146/annurev-biochem-052521-033250

Figure 7.

Figure 7.

The protomer conformations of IR with different numbers of insulin bound. Two different types of IR protomer conformations exist – compacted and extended. (a) The apo-IR consists of two extended protomers. (b) The ‘Ƭ’-shaped IR with two insulins bound consists of one extended protomer and one compacted protomer. (c) The ‘T’-shaped IR with four insulins bound consists of two compacted protomers.