FIGURE 7:

Reduced odd-chain lipids and increased 2-OH lipids in Hacl2 KO mice. Lipids were extracted from 17 tissues (brain, heart, lung, liver, pancreas, spleen, kidney, stomach, small intestine, large intestine, white adipose tissue, brown adipose tissue, submandibular glands, bronchus, uterus, skeletal muscle, and epidermis) of 2-mo-old WT (n = 3) and Hacl2 KO (n = 3) mice, and non-OH/2-OH FFAs, CERs, SMs, and HexCERs were quantified via LC-MS/MS. The changes in the quantities of non-OH even- and odd-chain lipids and of 2-OH lipids in Hacl2 KO mice relative to WT mice are shown as a heat map. WAT, white adipose tissue; BAT, brown adipose tissue; S. gland, submandibular gland; S. intestine, small intestine; L. intestine, large intestine; S. muscle, skeletal muscle.