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. 2023 Aug 1;34(9):ar93. doi: 10.1091/mbc.E23-02-0055

FIGURE 5:

FIGURE 5:

Ubiquitin differentially regulates ARRDC3 function in regulating GPCR signaling to the Hippo pathway. MDA-MB-231 cells were transduced with vector control, HA-ARRDC3-WT, or -AAXA lentivirus and stimulated with (A) 10 nM thrombin, (B) 10 μM SLIGKV, or (C) 100 nM LPA for the indicated times. Left: Lysates were immunoblotted for YAP/TAZ target gene CTGF. Right: Quantifications of CTGF induction (mean ± SD from four or five independent experiments; one-way ANOVA; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001).