Table 5.
Assessment of the quality of recommendations
| Subgroup | Outcomes | Number of trails | Number of patients | Follow-up (Y) | Relative effect (95% CI) | Quality of the evidence (GRADE) | ||
|---|---|---|---|---|---|---|---|---|
| SG | CG | |||||||
| Follow-up (2 years) | Collapse of the femoral head | 2 | 12/35 | 16/32 | 2 | OR 4.5 (0.07 to 307.07) |
⊕ ⊝ ⊝ ⊝ very low |
|
| Radiological progression | 5 | 16/103 | 31/105 | 2 | OR 2.49 (0.85 to 7.32) |
⊕ ⊕ ⊕ ⊝ moderate |
||
| Conversion to THA | 6 | 22/125 | 40/134 | 2 | OR 2.29 (1.07 to 4.88) |
⊕ ⊕ ⊕ ⊕ high |
||
| Follow-up (2–5 years) | Collapse of the femoral head | 5 | 54/177 | 56/126 | 3.2 | OR 2.41 (1.09 to 5.32) |
⊕ ⊕ ⊝ ⊝ low |
|
| Radiological progression | 6 | 48/225 | 75/185 | 4.0 | OR 4.5 (1.69 to 12.03) |
⊕ ⊝ ⊝ ⊝ very low |
||
| Conversion to THA | 8 | 42/276 | 63/214 | 3.5 | OR 2.42 (1.48 to 3.95) |
⊕ ⊕ ⊝ ⊝ low |
||
| Follow-up (> 5 years) | Collapse of the femoral head | 1 | 35/125 | 90/125 | 25 | OR 6.61 (3.81 to 11.49) |
⊕ ⊕ ⊝ ⊝ low |
|
| Conversion to THA | 3 | 82/274 | 116/176 | 14.1 | OR 3.17 (0.62 to 16.14) |
⊕ ⊝ ⊝ ⊝ very low |
||
| Subchondral (with mechanical support) | Collapse of the femoral head | 4 | 22/118 | 36/86 | 2.4 | OR 6.15 (1.91 to 19.74) |
⊕ ⊕ ⊝ ⊝ low |
|
| Radiological progression | 5 | 25/145 | 50/115 | 2.3 | OR 6.11 (3 to 12.46) |
⊕ ⊕ ⊕ ⊝ moderate |
||
| Conversion to THA | 7 | 16/188 | 43/164 | 3.4 | OR 3.73 (1.96 to 7.11) |
⊕ ⊕ ⊝ ⊝ low |
||
| Subchondral (without mechanical support) | Collapse of the femoral head | 4 | 79/219 | 126/197 | 3.2 | OR 1.82 (0.58 to 5.73) |
⊕ ⊝ ⊝ ⊝ very low |
|
| Radiological progression | 6 | 39/183 | 56/175 | 3.4 | OR 2.2 (0.88 to 5.53) |
⊕ ⊝ ⊝ ⊝ very low |
||
| Conversion to THA | 10 | 130/487 | 176/360 | 5.9 | OR 2.37 (1.12 to 5.04) |
⊕ ⊝ ⊝ ⊝ very low |
||
| Type of stem cells (BMAC) | Collapse of the femoral head | 4 | 66/201 | 115/176 | 8.2 | OR 2.78 (0.64 to 12.13) |
⊕ ⊝ ⊝ ⊝ very low |
|
| Radiological progression | 5 | 19/86 | 35/86 | 2.6 | OR 2.82 (0.96 to 8.3) |
⊕ ⊕ ⊕ ⊕ high |
||
| Conversion to THA | 11 | 123/433 | 168/320 | 5.8 | OR 2.53 (1.23 to 5.2) |
⊕ ⊝ ⊝ ⊝ very low |
||
| Type of stem cells (BMMSCs/BMMSs/PBSCs) | Collapse of the femoral head | 4 | 35/136 | 47/107 | 3.0 | OR 3.92 (1.17 to 13.14) |
⊕ ⊕ ⊝ ⊝ low |
|
| Radiological progression | 6 | 45/242 | 71/204 | 3.2 | OR 4.02 (0.88 to 18.29) |
⊕ ⊝ ⊝ ⊝ very low |
||
| Conversion to THA | 6 | 23/242 | 51/204 | 3.2 | OR 2.66 (1.28 to 5.5) |
⊕ ⊕ ⊝ ⊝ low |
||
CI confidence interval, OR Odds Ratio, BMAC bone marrow aspirate concentrate, BMMCs bone marrow mononuclear cells, BMMSCs bone marrow mesenchymal stem cells, PBSCs peripheral blood stem cells, THA total hip arthroplasty, GRADE Grading of Recommendations Assessment, Development and Evaluation