Fig. 7.

Hypothesis by which CI downregulation might foster MDST8 cell migration. The decrease in CI measured in MDST8 generates mtROS and hampers the production of NAD⁺, which become limiting for NAD⁺-dependent SIRT3 activity. Since, SIRT3 activity is mandatory for the induction of SOD2 activity by deacetylation, this results in decreased SOD2 enzyme activity in MDST8, contributing to maintain the levels of mtROS. In turn, these mtROS likely induce FAK activation, which participates to MDST8 migratory potential