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. 2023 Aug 2;13:141. doi: 10.1186/s13578-023-01092-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Higher amount of APP/APLP1/APLP2 dimerization is not visible in astrocytes, N2a cells or neurons. A, C, E One year old WT mouse cortices and APP KO mouse cortices were homogenized and compared with the lysate of astrocytes and N2a cells. All samples were prepared under semi-denaturing conditions for analysis on Blue Native gels. Western blot detection of APP followed with the primary α-APP C-terminal antibody Y188 (A), of APLP1 with the primary α-APLP1 antibody 57 (C) and APLP2 with the primary α-APLP2 antibody D2-II (E). B, D, F Mouse primary cortical neurons were cultivated for 5 or 19 days in vitro (DIV), lysed and compared to the lysate of 1 year old WT mouse cortices. All samples were prepared under semi-denaturing conditions for analysis on Blue Native gels. Western blot detection of APP followed with the primary α-APP C-terminal antibody Y188 (B), of APLP1 with the primary α-APLP1 antibody 57 (D) and APLP2 with the primary α-APLP2 antibody D2-II (F)