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. 2023 Aug 3;21:191. doi: 10.1186/s12964-023-01206-0

Fig. 4.

Fig. 4

eRNAs can facilitate RNAPII pause-release to enhance transcription extension. A eRNAs can promote the release of NELF by directly bind to NELF subunit, allowing the RNAPII to effectively transit to a productive transcription extension. B eRNAs can facilitate RNAPII pause-release by binding to P-TEFb complex subunit, activating P-TEFb and promoting RNAPII 2 phosphorylation