Table 3.

Multivariable MR analyses for the Causal Effect of RC on FI

Adjustment	β (95% CI)	P-value
TC and LDL-C	0.086 (0.012, 0.161)	0.024*
CHD	0.032 (0.006, 0.058)	0.001**
HF	0.043 (0.018, 0.067)	5.67E-04***
Stroke	0.051 (0.025, 0.076)	9.05E-05***
T2DM	0.068 (0.027, 0.108)	0.001**
BMI	0.069 (0.031, 0.107)	2.11E-04***
SBP	0.047 (0.021, 0.073)	4.30E-04
DBP	0.041 (0.015, 0.067)	0.002**

Notes: The effect size (β) is per 1 mmol/L increase in RC. LDL-C Low-density lipoprotein cholesterol, TC Total cholesterol, T2DM Type 2 diabetes mellitus, HF Heart failure, BMI Body mass index. *, < 0.05; **, < 0.01; ***, < 0.001