Figure 1.

Treatment approaches (A), response of pulmonary bleeds (B) and non-relapse related mortality (C). (A) In this sankey diagram, combinations of treatments for DAH and the response of treatments are indicated for each pulmonary bleed. Not all bleeds were treated; 37 patients received treatment for first pulmonary bleed. Sustained complete response (sCR) was defined as cessation of bleeding without a rebleed. CR as cessation of bleeding for ≥24 hours, but with a recurrent bleed, and no response (NR) as continued bleeding or death with bleeding. (B) Response rates of each pulmonary bleed to each agent; notably, many patients received multiple agents. (C) Overall response to each agent. As above, multiple drugs were given concurrently; assessment of response was the same for all concurrently administered drugs.