Fig. 4.

Periventricular white matter hyperintensity (WMH) damage field progression evaluated at 0%, 10%, 12.5%, 15%, 17.5%, and 20% ventricular enlargement for each of our eight models. We observe various damage onset times and spatial progression behaviors that are dependent on initial ventricle and brain shape. We obtain the periventricular WMH damage field after binarizing the damage field variable c which allows us to differentiate between healthy white matter, normal-appearing white matter, and periventricular WMH. We summarized periventricular WMH areas in Table 1 in the Appendix.