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. 2023 Jun 12;27(15):2215–2227. doi: 10.1111/jcmm.17809

FIGURE 2.

FIGURE 2

Treatment with melatonin (24 h) impaired the expression of cytoskeleton and matrix metalloprotein‐associated genes. (A) Expression of cytoskeleton‐related genes evaluated by RT‐qPCR. (B) Expression of matrix metalloprotein associated genes as determined by RT‐qPCR. (C–G) Self‐renewal capability of cells treated with 0 (D), 1.0 (E), 2.5 (F) and 5.0 mM (G) of melatonin, assessed by soft agar assay. Data are presented as mean ± SEM of duplicate experiments. *p < 0.05 and **p < 0.01, indicate significant differences relative to the control group.