TABLE 1.
Association of TET1 gene polymorphisms with neuroblastoma risk in children from Jiangsu province.
| Genotype | Cases (n = 400) | Controls (n = 473) | p a | Crude OR (95% CI) | p | Adjusted OR (95% CI) b | p b |
|---|---|---|---|---|---|---|---|
| rs16925541 A > G (HWE = 0.142) | |||||||
| AA | 308 (77.00) | 365 (77.17) | 1.00 | 1.00 | |||
| AG | 77 (19.25) | 97 (20.51) | 0.94 (0.67–1.32) | 0.722 | 0.94 (0.67–1.32) | 0.722 | |
| GG | 15 (3.75) | 11 (2.33) | 1.62 (0.73–3.57) | 0.235 | 1.63 (0.73–3.60) | 0.231 | |
| Additive | 0.641 | 1.07 (0.82–1.39) | 0.640 | 1.07 (0.82–1.39) | 0.637 | ||
| Dominant | 92 (23.00) | 108 (22.83) | 0.953 | 1.01 (0.74–1.39) | 0.953 | 1.01 (0.74–1.39) | 0.952 |
| AA/AG | 385 (96.25) | 462 (97.67) | 1.00 | 1.00 | |||
| GG | 15 (3.75) | 11 (2.33) | 0.217 | 1.64 (0.74–3.61) | 0.221 | 1.65 (0.75–3.64) | 0.217 |
| rs3998860 G > A (HWE = 0.582) | |||||||
| GG | 276 (69.00) | 319 (67.44) | 1.00 | 1.00 | |||
| GA | 96 (24.00) | 141 (29.81) | 0.79 (0.58–1.07) | 0.124 | 0.79 (0.58–1.07) | 0.128 | |
| AA | 28 (7.00) | 13 (2.75) | 2.49 (1.26–4.90) | 0.008 | 2.51 (1.27–4.95) | 0.008 | |
| Additive | 0.488 | 1.09 (0.86–1.37) | 0.487 | 1.09 (0.86–1.38) | 0.478 | ||
| Dominant | 124 (31.00) | 154 (32.56) | 0.623 | 0.93 (0.70–1.24) | 0.623 | 0.93 (0.70–1.24) | 0.628 |
| GG/GA | 372 (93.00) | 460 (97.25) | 1.00 | 1.00 | |||
| AA | 28 (7.00) | 13 (2.75) | 0.003 | 2.66 (1.36–5.21) | 0.004 | 2.69 (1.37–5.27) | 0.004 |
| rs12781492 A > C (HWE = 0.279) | |||||||
| AA | 303 (75.75) | 348 (73.57) | 1.00 | 1.00 | |||
| AC | 74 (18.50) | 112 (23.68) | 0.76 (0.55–1.06) | 0.103 | 0.76 (0.54–1.06) | 0.103 | |
| CC | 23 (5.75) | 13 (2.75) | 2.03 (1.01–4.08) | 0.046 | 2.04 (1.01–4.10) | 0.046 | |
| Additive | 0.822 | 1.03 (0.80–1.32) | 0.822 | 1.03 (0.80–1.32) | 0.819 | ||
| Dominant | 97 (24.25) | 125 (26.43) | 0.462 | 0.89 (0.66–1.21) | 0.462 | 0.89 (0.66–1.21) | 0.462 |
| AA/AC | 377 (94.25) | 460 (97.25) | 1.00 | 1.00 | |||
| CC | 23 (5.75) | 13 (2.75) | 0.026 | 2.16 (1.08–4.32) | 0.030 | 2.17 (1.08–4.34) | 0.029 |
| Combine risk genotypes c | |||||||
| 0 | 360 (90.00) | 456 (96.41) | 1.00 | 1.00 | |||
| 1–3 | 40 (10.00) | 17 (3.59) | 0.0001 | 2.98 (1.66–5.34) | 0.0002 | 3.01 (1.67–5.40) | 0.0002 |
Note: Values are in bold if the p values are less than 0.05 or the 95% CIs excluded 1.
Abbreviations: CI, confidence interval; HWE, Hardy–Weinberg equilibrium; OR, odds ratio.
a
χ2 test for genotype distributions between neuroblastoma patients and cancer‐free controls.
b
Adjusted for age and sex.
c
Risk genotypes were carriers with rs16925541 GG, rs3998860 AA and rs12781492 CC genotypes.