Figure 6.

Differential activation of signaling pathways in Mu-1 cells. IPA results of relevant selected up- or down-regulated pathways at 48 hours, and day 5 after light injury compared with baseline are shown as heat map for selected cell types. The cell types shown are Mu-1, Mu-2, rods (R), cones (C), ON-cone bipolar cells (CB-On), OFF-cone bipolar (CB-Off), amacrine GABAergic (A, GABA), amacrine glycinergic (A, Gly), and RGCs. Significantly upregulated (red) or down-regulated (blue) pathways differ for Mu-1 cells compared with other cell types. Pathways are considered as significantly regulated if they meet a P value of <0.05 and a |Z-score| of >2.0.