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. 2023 Mar 9;17(8):1545–1566. doi: 10.1002/1878-0261.13414

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© 2023 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 5 — Role of colonic glucocorticoid synthesis in intestinal tumour development. (A) Scheme of AOM/DSS‐induced intestinal tumour induction. (B) Weight loss curve of control (Cyp11b1^fl/fl) and Cyp11b1^{IEC KO} mice after AOM/DSS treatment. Mean values ± SD of pooled three independent experiments are shown (n = 6–13 mice per group). Unpaired Student's t‐test, *P < 0.05. (C) Colonic tumour development (arrows) in Cyp11b1^fl/fl and Cyp11b1^{IEC KO} mice at days 35 and 56. (D) Colonic tumour numbers in Cyp11b1^fl/fl and Cyp11b1^{IEC KO} mice at days 35 and 56 (n = 6–7 mice per group and time point). Unpaired Student's t‐test, *P < 0.05. (E) Detection of immune checkpoints (Cd279, Cd274, Cd152), M2 macrophage marker (Arg1) and cytokines (Tnf, IL6, Tgfb, Il10) in Cyp11b1^fl/fl and Cyp11b1^{IEC KO} tumours at day 48 (n = 4–5 mice). Unpaired Student's t‐test, P‐values are indicated.