Table 1.

Cross‐analysis of clinical information and TLS enrichment group (TCGA). Results are based on nonempty rows and columns in each innermost subtable.

	TLS cluster						P‐value
	TLS‐H		TLS‐M		TLS‐L
	Count	Per cent	Count	Per cent	Count	Per cent
Gender
Male	172	69.90	181	76.40	14	82.40	0.192
Female	74	30.10	56	23.60	3	17.60
Age
< 60	101	41.10	111	46.80	9	52.90	0.336
≥ 60	145	58.90	126	53.20	8	47.10
Location
Oral cavity	42	17.10	28	11.80	2	11.80	0.394 a
Oral floor	26	10.60	31	13.10	3	17.60
Oral tongue	80	32.50	64	27.00	4	23.50
Oropharynx	73	29.70	90	38.00	5	29.40
Others	25	10.20	24	10.10	3	17.60
Stage
I–II	65	27.30	44	19.00	5	29.40	0.09
III–IV	173	72.70	187	81.00	12	70.60
T
T1–T2	100	42.20	70	30.30	6	35.30	0.028*
T3–T4	137	57.80	161	69.70	11	64.70
N
N0–N1	147	63.10	160	70.20	12	70.60	0.834 a , b
N2–N3	86	36.90	68	29.80	5	29.40
M
M0	230	98.70	223	99.10	17	100.00	0.256
M1	3	1.30	2	0.90	0	0.00
Grade
G1–G2	169	71.30	182	79.50	11	64.70	0.077
G3–G4	68	28.70	47	20.50	6	35.30

^a More than 20% of cells in this subtable have expected cell counts < 5. Chi‐square results may be invalid.

^b The minimum expected cell count in this subtable is < 1. Chi‐square results may be invalid.

^*The chi‐square statistic is significant at the 0.05 level.