Table 1.
Prognostic value of CD103+CD8+ TRM cells in various types of cancer.
| Tumor type | Observations | References |
|---|---|---|
| Bladder cancer | High CD103+ TIL densities are a good prognostic factor (DFS and OS) | (21) |
| Breast cancer | High CD8+CD103+ intratumoral T cell densities are a good prognostic factor in basal-like subsets (OS) | (108) |
| The CD8+ TRM cell signature is associated with a good prognosis (DFS and OS) | (19) | |
| An enrichment in CD8+CD103+ TRM cells in tumoral islets is associated with a good prognosis (relapse-free) | (109) | |
| Cervical cancer | CD103 expression is a good prognostic factor for disease-specific survival | (110) |
| Colorectal cancer | CD8+CD103+ T cells are more important in the tumoral epithelium than in healthy epithelium | (20) |
| Endometrial cancer | High CD8+CD103+ T-cell densities are a good prognostic factor (disease-specific survival) | (84) |
| Esophageal cancer | High CD8+CD103+ TRM cell densities are a good prognostic factor (OS) | (111) |
| Gastric cancer | CD8+CD69+CD103+ TRM cell densities are a good prognostic factor (OS) but these cells are less frequently present in metastatic cancers | (112) |
| High intratumoral CD8+CD103+ T cell densities are associated with better OS | (113) | |
| CD8+CD103+ TRM cell numbers are a good prognostic factor (OS and DFS) | (114) | |
| Head-and-neck cancer | CD8+CD103+CD39+ TIL densities are a good prognostic factor (OS) | (29) |
| Hepatocellular carcinoma | High CD103+PD-1+ T-cell numbers are associated with good prognostic factor (DFS) | (115) |
| HBV-specific CD8+ T cells numbers defined as expressing CD69+ and CD103+ are good prognostic factor (Tumor relapse-free survival) | (116) | |
| Lung cancer | An enrichment in CD8+CD103+ TIL in the epithelium is associated with a good prognosis (OS) | (16) |
| CD8+CD103+ TIL densities are a good prognostic factor (OS) | (18) | |
| CD8+CD103+ TIL densities are a good prognostic factor (OS) | (25) | |
| CD8+CD103+ TIL densities are a good prognostic factor (OS) | (17) | |
| Melanoma | CD8+VLA-1+ TIL are associated with better survival (OS and DFS) | (38) |
| CD8+ CD103+ TRM cell densities are a good prognostic factor (survival proportion) | (117) | |
| Oropharyngeal cancer | High levels of CD8+CD103+ TRM are associated with a good prognosis (OS) | (118) |
| Ovarian cancer | CD8+CD103+ TIL are more frequent in high-grade cancers than in other cancers and are a good prognostic factor (DFS) | (15) |
| CD8+PD-1+CD103+ TIL densities are a good prognostic factor (OS) | (24) | |
| CD3highCD103high TIL densities are a good prognostic factor (OS) | (119) | |
| Pancreatic cancer | The ratio of intraepithelial TIL levels to CD8+CD103+ TIL levels is a good prognostic factor (DFS and OS) | (120) |
Non-exhaustive. TIL, tumor-infiltrating lymphocytes; OS, overall survival; DFS, disease-free survival.