Table 1.
Demographics and clinical characteristics of each cohort
| Clinical Characteristic | Kidney Donors (n=3020) | Patients with Kidney Tumor (n=1363) | Patients with Kidney Disease (N=314) |
|---|---|---|---|
| Mean (SD), Median (IQR), or n (%) | |||
| Demographic | |||
| Age, yr | 44.1 (12.1) | 64.0 (11.9) | 53.4 (18.0) |
| Men, % | 1235 (40.9) | 873 (64.0) | 167 (53.2) |
| Race | |||
| White or unknown | 2772 (91.8) | 1306 (95.8) | 289 (92.1) |
| Black | 92 (3.0) | 22 (1.6) | 11 (3.5) |
| American Indian/Alaskan Native | 48 (1.6) | 15 (1.1) | 1 (0.3) |
| Asian | 43 (1.4) | 4 (0.3) | 13 (4.1) |
| Other | 65 (2.2) | 16 (1.2) | 0 (0.0) |
| CKD risk factors at baseline | |||
| BMI, kg/m2 | 27.5 (4.8) | 30.8 (6.7) | 29.2 (6.9) |
| Diabetes mellitus, % | 0 (0) | 185 (13.6) | 73 (23.2) |
| Hypertension, % | 437 (14.5) | 919 (67.4) | 206 (65.6) |
| Kidney function at baseline | |||
| Measured GFR, ml/min per 1.73 m2 | 104.1 (19.7) | — | — |
| eGFR, ml/min per 1.73 m2 | 100.0 (16.2) | 51.1 (13.8) | 62.7 (31.8) |
| 24-h urine protein, mga | 63 (52–94) | 154 (87–307) | 1913 (583–4372) |
| Kidney biopsy findings at baseline | |||
| Total no. of glomeruli on biopsy | 20.4 (11.1) | 337.3 (155.5) | 11.0 (8.9) |
| Nephron size | |||
| Glomerular tuft volume, mm3 | 0.0026 (0.0011) | 0.0028 (0.0010) | 0.0042 (0.0029) |
| Nonsclerosed cortex per glomerulus, mm3 | 0.057 (0.028) | 0.071 (0.028) | 0.110 (0.113) |
| Nephrosclerosis | |||
| Globally sclerosed glomeruli, % | 2.9 (5.3) | 8.6 (8.7) | 21.1 (22.9) |
| IFTA, % | 0.3 (1.2) | 3.6 (7.5) | 15.3 (17.7) |
| IFTA density, foci per cm2 cortex | 4.4 (11.8) | 25.1 (20.9) | 79.1 (77.2) |
| Luminal stenosis (arteriosclerosis), %b | 35.1 (17.6) | 54.5 (15.5) | 43.5 (18.3) |
| Progressive CKD outcome | |||
| Kidney failure or 40% decline in eGFR | — | 126 (9.2) | 171 (54.5) |
BMI, body mass index; IFTA, interstitial fibrosis and tubular atrophy.
a
Twenty-four–hour urine protein missing in 42 donors, 178 patients with tumor, and four native biopsy patients.
b
Missing in 80 donors because of lack of an artery.