Table 2.
Age-based thresholds for nephrosclerosis measures (≥95th percentile) in 2583 normotensive kidney donors
| Nephrosclerosis Measures | %GSG | %IFTA | IFTA Foci Density | ||||
|---|---|---|---|---|---|---|---|
| Age Groups (Mean) | N | 95th Percentile Threshold, %a | Abnormal, n (%) | 95th Percentile Threshold, % | Abnormal, n (%) | 95th Percentile Threshold, per cm2 | Abnormal, n (%) |
| 18–29 yr (25 yr) | 396 | ≥1.7 | 27 (6.8) | ≥0.18 | 20 (5.1) | ≥8.2 | 20 (5.1) |
| 30–39 yr (35 yr) | 678 | ≥4.1 | 31 (4.6) | ≥0.53 | 34 (5.0) | ≥14.6 | 34 (5.0) |
| 40–49 yr (45 yr) | 792 | ≥6.6 | 36 (4.5) | ≥1.0 | 40 (5.1) | ≥18.4 | 40 (5.1) |
| 50–59 yr (54 yr) | 519 | ≥9.1 | 19 (3.7) | ≥2.0 | 26 (5.0) | ≥33.6 | 26 (5.0) |
| 60–69 yr (64 yr) | 180 | ≥12 | 8 (4.4) | ≥3.3 | 9 (5.0) | ≥47.2 | 9 (5.0) |
| 70+ yr (72 yr) | 18 | ≥16 | 1 (5.6) | ≥6.5 | 1 (5.6) | ≥59.3 | 1 (5.6) |
GSG, globally sclerotic glomeruli; IFTA, interstitial fibrosis and tubular atrophy.
a
Threshold shown for normotensive kidney donors with 48.1–91.4 glomeruli on biopsy; the 95th percentile threshold for % globally sclerotic glomeruli increased when fewer glomeruli were present on biopsy (See Supplemental Table 1 for 95th percentile thresholds used when 48 or fewer glomeruli are present on biopsy).24