Table 4.

Globally sclerotic glomeruli, %IFTA, IFTA foci density categories as predictors of progressive CKD in 1363 patients with tumor and 314 patients with kidney disease (age-adjusted).

Nephrosclerosis Measure	Patients with Kidney Tumor (N=1363)		Patients with Kidney Disease (N=314)
	HR (95% CI)	P Value	HR (95% CI)	P Value
Three categories
Globally sclerotic glomeruli
Normal compared with young	Ref	Ref	Ref	Ref
Normal for age but abnormal compared  with young	0.74 (0.38 to 1.47)	0.39	1.40 (0.89 to 2.20)	0.15
Abnormal for age	1.74 (0.85 to 3.57)	0.13	2.12 (1.49 to 3.02)	<0.001
%IFTA
Normal compared with young	Ref	Ref	Ref	Ref
Normal for age but abnormal compared  with young	0.69 (0.34 to 1.39)	0.30	1.42 (0.63 to 3.21)	0.39
Abnormal for age	1.75 (0.87 to 3.53)	0.12	3.37 (1.68 to 6.78)	<0.001
IFTA foci density
Normal compared with young	Ref	Ref	Ref	Ref
Normal for age but abnormal compared  with young	1.26 (0.70 to 2.27)	0.44	1.47 (0.66 to 3.28)	0.35
Abnormal for age	2.46 (1.29 to 4.71)	0.007	4.08 (2.02 to 8.25)	<0.001
Two categories
Global glomerulosclerosis
Normal for age	Ref	Ref	Ref	Ref
Abnormal for age	2.28 (1.58 to 3.30)	<0.0001	1.87 (1.38 to 2.53)	<0.001
%IFTA
Normal for age	Ref	Ref	Ref	Ref
Abnormal for age	2.41 (1.68 to 3.47)	<0.0001	2.65 (1.80 to 3.89)	<0.001
IFTA foci density
Normal for age	Ref	Ref	Ref	Ref
Abnormal for age	2.03 (1.34 to 3.08)	0.0009a	3.11 (2.13 to 4.54)	<0.001

CI, confidence interval; IFTA, interstitial fibrosis and tubular atrophy; HR, Hazard Ratio.