Table 3.
Change from baseline in cardiac parameters according to the treatment group
| Parameter | Placebo | Sodium Bicarbonate | P Value |
|---|---|---|---|
| Ejection fraction, % | |||
| Baseline | 67.1 (60.3, 72.2) | 68.1 (55.9, 73.0) | |
| End of study | 65.3 (59.1, 69.4) | 65.0 (57.8, 73.2) | |
| Change from baseline | −1.9 (−5.3, 2.1) | −0.7 (−6.7, 3.0) | 0.41 |
| Stroke volume, ml | |||
| Baseline | 71.3 (59.4, 82.3) | 67.9 (60.5, 78.9) | |
| End of study | 72.2 (58.6, 82.4) | 68.9 (54.9, 87.4) | |
| Change from baseline | −1.3 (−9.0, 10.3) | −3.6 (−13.7, 5.7) | 0.13 |
| Cardiac output, L/min | |||
| Baseline | 4.7 (4.0, 5.9) | 4.7 (4.1, 5.8) | |
| End of study | 4.7 (4.2, 5.6) | 4.5 (3.4, 5.7) | |
| Change from baseline | −0.2 (−0.5, 0.8) | −0.2 (−1.1, 0.4) | 0.21 |
| LVMI, g/m2 | |||
| Baseline | 59.4 (51.4, 76.1) | 57.4 (51.5, 67.9) | |
| End of study | 67.6 (51.6, 78.3) | 57.2 (53.1, 66.8) | |
| Change from baseline | −1.6 (−9.7, 6.5) | 2.7 (−4.1, 6.6) | 0.51 |
The median and IQR at baseline and at the end of the study were calculated using all available data. The median (IQR) of the pre-post change were calculated for only those with data both before and after intervention. P values were calculated by the two-group t test in comparison of the pre-post change. LVMI, left ventricular mass index; IQR, interquartile range.