Table 5.

Adverse events

Adverse Event	Placebo N=54	Sodium Bicarbonate N=55
Serious adverse events
No. of hospitalizations, N (%)	6 (11.1)	6 (10.9)
Reasons for hospitalizations
Infections	1 (1.9)	1 (1.8)
Volume overload	1 (1.9)	0
MI/stroke	1 (1.9)	1 (1.8)
Acute on chronic renal failure	1 (1.9)	0
Surgery	2 (3.7)	0
Ileus	0	1 (1.8)
High/low glucose levels	0	2 (3.6)
Loss of consciousness	0	1 (1.8)
No. of deaths, N (%)	1 (1.9)	0
Deaths related to the study	0	0
Chronic dialysis initiation, N (%)	1 (1.9)	1 (1.8)
Adverse events
New edema, N (%)	1 (2.2)	1 (2.3)
Increase in diuretic therapy, N (%)	7 (12.9)	8 (14.5)
Increase in antihypertensive therapy, N (%)	12 (22.2)	11 (20.0)
High serum bicarbonate level (>28 mEq/L), N (%)	1 (1.9)	13 (23.6)a
Low serum bicarbonate level (<20 mEq/L), N (%)	8 (14.8)	4 (7.3)

^aP value <0.05.