Table 3.
Association of a first-time symptomatic kidney stone with different periods of antibiotic use among stone formers and matched controls with no prior urinary symptoms within 5 years (N=4294)
| Time from Last Antibiotic to Index Date | Stone Formers (N=892) | Controls (N=3402) | Unadjusted | Adjusteda | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |||
| 1 d–1 yr, n (%) | 226 (25.3) | 845 (24.8) | 1.04 (0.85 to 1.27) | 0.70 | 0.95 (0.78 to 1.17) | 0.64 |
| 1–2 yr, n (%) | 115 (12.9) | 438 (12.9) | 1.01 (0.79 to 1.29) | 0.94 | 0.96 (0.75 to 1.24) | 0.78 |
| 2–5 yr, n (%) | 174 (19.5) | 745 (21.9) | 0.91 (0.74 to 1.13) | 0.39 | 0.87 (0.70 to 1.08) | 0.20 |
| No antibiotics,b n (%) | 377 (42.3) | 1374 (40.4) | REF | REF | REF | REF |
P-values derived from conditional logistic regression models to account for age and sex matching. P-values denote statistical significance at the 0.05 α level. OR, odds ratio; CI, confidence interval.
a
Adjusted for ethnicity, obesity, diabetes, hypertension, and CKD.
b
No antibiotics prescribed within 5 years before the index date.