Table 1.
Genes that were upregulated in the kidneys of CKO compared with Cont mice
| Gene Symbol | Gene Name | Fold Change | Genbank Accession |
|---|---|---|---|
| Ucp1 | Uncoupling protein 1 (mitochondrial, proton carrier) | 26.625 | NM_009463 |
| Cox8b | Cytochrome c oxidase subunit 8B | 11.979 | NM_007751 |
| Ctxn3 | Cortexin 3 | 11.540 | NM_001134697 |
| Cidea | Cell death–inducing DNA fragmentation factor, α subunit-like effector A | 10.868 | NM_007702 |
| Hp | Haptoglobin | 10.756 | NM_001329965 |
| Rgs14 | Regulator of G-protein signaling 14 | 5.484 | NM_016758 |
| Mrap | Melanocortin 2 receptor accessory protein | 4.802 | NM_029844 |
| Bcl6 | B-cell leukemia/lymphoma 6 | 4.584 | AK046709 |
| Rem1 | rad and gem–related GTP binding protein 1 | 4.571 | AK078772 |
| Nat8f5 | N-acetyltransferase 8 (GCN5-related) family member 5 | 4.514 | NM_023493 |
| Car3 | Carbonic anhydrase 3 | 4.496 | NM_007606 |
| Slc16a14 | Solute carrier family 16 (monocarboxylic acid transporters), member 14 | 4.429 | NM_027921 |
| Adig | Adipogenin | 4.065 | NM_145635 |
| Slc16a14 | Solute carrier family 16 (monocarboxylic acid transporters), member 14 | 4.011 | XM_006496551 |
| Apoh | Apolipoprotein H | 3.935 | NM_013475 |
| Ppbp | Proplatelet basic protein | 3.862 | NM_023785 |
| Cyp4a12a | Cytochrome P450, family 4, subfamily a, polypeptide 12a | 3.734 | NM_177406 |
| Cyp4a12b | Cytochrome P450, family 4, subfamily a, polypeptide 12B | 3.681 | NM_172306 |
| Plin4 | Perilipin 4 | 3.677 | NM_020568 |
| Apoc1 | Apolipoprotein C-I | 3.647 | NM_007469 |
| Clstn3 | Calsyntenin 3 | 3.616 | NM_153508 |
| Zfp458 | Zinc finger protein 458 | 3.615 | NM_001001152 |
| Sfpq | Splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) | 3.596 | XR_001784200 |
| Hk2 | Hexokinase 2 | 3.593 | NM_013820 |
| Derl3 | Der1-like domain family, member 3 | 3.535 | NM_024440 |
| Gm8016 | Predicted gene 8016 | 3.459 | NR_152173 |
| Prkar2b | Protein kinase, cAMP-dependent regulatory, type II β | 3.351 | NM_011158 |
| F13a1 | Coagulation factor XIII, A1 subunit | 3.343 | NM_028784 |
| S100a8 | S100 calcium binding protein A8 (calgranulin A) | 3.282 | NM_013650 |
| Rbp7 | Retinol binding protein 7, cellular | 3.269 | NM_022020 |
| Thrsp | Thyroid hormone responsive | 3.126 | NM_009381 |
| Gm16982 | Predicted gene, 16982 | 3.066 | NR_040337 |
| Slc36a2 | Solute carrier family 36 (proton/amino acid symporter), member 2 | 3.050 | AK079219 |
| S100a9 | S100 calcium binding protein A9 (calgranulin B) | 3.025 | NM_001281852 |
| Col19a1 | Collagen, type XIX, α 1 | 2.924 | NM_007733 |
| Adamts4 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type-1 motif, 4 | 2.851 | NM_172845 |
| Atp1a2 | ATPase, Na+/K+transporting, α 2 polypeptide | 2.829 | NM_178405 |
| Kcnk3 | Potassium channel, subfamily K, member 3 | 2.804 | NM_010608 |
| Pisd-ps3 | Phosphatidylserine decarboxylase, pseudogene 3 | 2.741 | NR_003518 |
| Gp9 | Glycoprotein 9 (platelet) | 2.696 | NM_018762 |
| Oxct2b | 3-oxoacid CoA transferase 2B | 2.644 | NM_181859 |
| Sec14l4 | SEC14-like lipid binding 4 | 2.620 | NM_146013 |
| Fabp4 | Fatty acid binding protein 4, adipocyte | 2.573 | NM_024406 |
| B3galt2 | UDP-Gal:βGlcNAc β 1,3-galactosyltransferase, polypeptide 2 | 2.559 | NM_020025 |
| Meox2 | Mesenchyme homeobox 2 | 2.555 | NM_008584 |
| Apod | Apolipoprotein D | 2.545 | NM_007470 |
| Inhbb | Inhibin β-B | 2.525 | NM_008381 |
| S100b | S100 protein, β polypeptide, neural | 2.522 | NM_009115 |
| Nrg4 | Neuregulin 4 | 2.500 | AK080089 |
| Gm40812 | Predicted gene, 40812 | 2.443 | XR_872234 |
| Gm33272 | Predicted gene, 33272 | 2.421 | XR_001782921 |
| Ttr | Transthyretin | 2.413 | NM_013697 |
| Vmn1r197 | Vomeronasal 1 receptor 197 | 2.408 | NM_134244 |
| Penk | Preproenkephalin | 2.400 | NM_001002927 |
| Gm33272 | Predicted gene, 33272 | 2.389 | XR_001782921 |
| Fabp4 | Fatty acid binding protein 4, adipocyte | 2.375 | NM_024406 |
| Zfp874a | Zinc finger protein 874a | 2.364 | AK136394 |
| Serpina1a | Serine (or cysteine) peptidase inhibitor, clade A, member 1A | 2.358 | NM_001252569 |
| Gm33272 | Predicted gene, 33272 | 2.350 | XR_001782921 |
| Wnt10a | Wingless-type MMTV integration site family, member 10A | 2.345 | NM_009518 |
| Nrg4 | Neuregulin 4 | 2.336 | NM_032002 |
| Uqcc1 | Ubiquinol–cytochrome c reductase complex assembly factor 1 | 2.334 | XM_011239706 |
| Maged1 | Melanoma antigen, family D, 1 | 2.327 | LF202122 |
| Trarg1 | Trafficking regulator of GLUT4 (SLC2A4) 1 | 2.318 | NM_177709 |
| Tnfrsf25 | Tumor necrosis factor receptor superfamily, member 25 | 2.303 | NM_001291010 |
| Pgbd5 | piggyBac transposable element derived 5 | 2.303 | NM_171824 |
| Nrg4 | Neuregulin 4 | 2.268 | NM_032002 |
| 1700018B24Rik | Enhancer of rudimentary homolog pseudogene | 2.257 | NR_003617 |
| Gm8765 | Predicted gene 8765 | 2.250 | NM_001244649 |
| Arxes2 | Adipocyte-related X-chromosome expressed sequence 2 | 2.250 | NM_029823 |
| C78197 | Expressed sequence C78197 | 2.246 | AK041628 |
| Mmp3 | Matrix metallopeptidase 3 | 2.241 | NM_010809 |
| Ttr | Transthyretin | 2.239 | NM_013697 |
| 4930502E18Rik | RIKEN cDNA 4930502E18 gene | 2.238 | XM_006535359 |
| Apod | Apolipoprotein D | 2.208 | NM_007470 |
| Hesx1 | Homeobox gene expressed in ES cells | 2.205 | NM_010420 |
| Cyp4f15 | Cytochrome P450, family 4, subfamily f, polypeptide 15 | 2.188 | NM_134127 |
| Cpe | Carboxypeptidase E | 2.185 | NM_013494 |
| Nrg4 | Neuregulin 4 | 2.182 | NM_032002 |
| Nr4a1 | Nuclear receptor subfamily 4, group A, member 1 | 2.177 | NM_010444 |
| Uqcc1 | Ubiquinol–cytochrome c reductase complex assembly factor 1 | 2.175 | AK054294 |
| 4930535E02Rik | RIKEN cDNA 4930535E02 gene | 2.174 | AK015977 |
| Myom3 | Myomesin family, member 3 | 2.146 | NM_001085509 |
| Ccdc33 | Coiled-coil domain containing 33 | 2.145 | NM_001311085 |
| Igf2bp1 | Insulin-like growth factor 2 mRNA binding protein 1 | 2.119 | NM_009951 |
| Slc36a2 | Solute carrier family 36 (proton/amino acid symporter), member 2 | 2.113 | AK086373 |
| Rbm3 | RNA binding motif (RNP1, RRM) protein 3 | 2.094 | NM_016809 |
| Polr3e | Polymerase (RNA) III (DNA directed) polypeptide E | 2.087 | NM_025298 |
| Gm41572 | Predicted gene, 41572 | 2.060 | XR_876756 |
| Tfec | Transcription factor EC | 2.049 | AK157426 |
| Slc25a48 | Solute carrier family 25, member 48 | 2.047 | NM_177809 |
| C4b | Complement component 4B (Chido blood group) | 2.041 | NM_009780 |
| Pzp | PZP, α-2 macroglobulin like | 2.039 | NM_007376 |
| C4a | Complement component 4A (Rodgers blood group) | 2.036 | NM_011413 |
| Il34 | Interleukin 34 | 2.023 | NM_029646 |
| Fcamr | Fc receptor, IgA, IgM, high affinity | 2.014 | NM_144960 |
| Pzp | PZP, α-2 macroglobulin like | 2.013 | NM_007376 |
| Slco4a1 | Solute carrier organic anion transporter family, member 4a1 | 2.001 | LF193827 |
| Dgkb | Diacylglycerol kinase, β | 1.992 | NM_001361686 |
| Pcdh7 | Protocadherin 7 | 1.989 | NM_018764 |
| Dmkn | Dermokine | 1.986 | NM_001166173 |
| Pparg | Peroxisome proliferator–activated receptor γ | 1.985 | NM_011146 |
| Atp1a2 | ATPase, Na+/K+transporting, α 2 polypeptide | 1.960 | NM_178405 |
| Catsper3 | Cation channel, sperm associated 3 | 1.950 | NM_029772 |
| Aldh3a2 | Aldehyde dehydrogenase family 3, subfamily A2 | 1.950 | NR_138545 |
| Nnmt | Nicotinamide N-methyltransferase | 1.947 | NM_010924 |
| C4b | Complement component 4B (Chido blood group) | 1.937 | NM_009780 |
| Treml1 | Triggering receptor expressed on myeloid cells like 1 | 1.936 | NM_027763 |
| Terc | Telomerase RNA component | 1.925 | NR_001579 |
| Rpp40 | Ribonuclease P 40 subunit | 1.916 | AK048810 |
| Il34 | Interleukin 34 | 1.912 | NM_029646 |
| Noct | Nocturnin | 1.908 | NM_009834 |
| Gm9951 | Predicted gene 9951 | 1.905 | AK040144 |
| Necab2 | N-terminal EF-hand calcium binding protein 2 | 1.904 | NM_054095 |
| Psat1 | Phosphoserine aminotransferase 1 | 1.903 | NM_001205339 |
| Serpina1a | Serine (or cysteine) peptidase inhibitor, clade A, member 1A | 1.903 | NM_001252569 |
| Gm5105 | Predicted gene 5105 | 1.901 | NR_037975 |
| Arhgef1 | Rho guanine nucleotide exchange factor (GEF) 1 | 1.901 | XM_006539565 |
| Duox2 | Dual oxidase 2 | 1.892 | AK079781 |
| Pappa2 | Pappalysin 2 | 1.882 | NM_001085376 |
| B3gat1 | β-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | 1.881 | NM_001310766 |
| Slc1a3 | Solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 1.880 | NM_148938 |
| Nnmt | Nicotinamide N-methyltransferase | 1.879 | NM_001311062 |
| Noct | Nocturnin | 1.876 | NM_009834 |
| Serpina1b | Serine (or cysteine) preptidase inhibitor, clade A, member 1B | 1.876 | NM_009244 |
| Ebf3 | Early B cell factor 3 | 1.868 | NM_010096 |
| Prr18 | Proline rich 18 | 1.867 | NM_178774 |
| Chil3 | Chitinase-like 3 | 1.865 | NM_009892 |