Table 4.
Patterns of recurrence after liver resection with wide- and narrow-margin.
| Parameters | The entire cohort (n, %) | |||||
|---|---|---|---|---|---|---|
| Wide margin | Narrow margin | |||||
| No TACE (n =186) |
TACE (n = 211) |
P | No TACE (n = 112) |
TACE (n = 161) |
P | |
| No. of recurrent cases | 81(43.5) | 92(43.6) | 1.000 | 74(66.1) | 90(55.9) | .118 |
| Time to recurrence, months | ||||||
| ≤24 | 74(39.7) | 69(32.7) | .173 | 64(57.1) | 74(46.0) | .090 |
| Type of recurrence | ||||||
| Intrahepatic | 58(31.2) | 62(29.3) | .779 | 59(52.6) | 63(39.1) | .036 |
| Extrahepatic | 15(8.0) | 18(8.6) | 1.000 | 9(8.0) | 17(10.6) | .648 |
| Intra-plus extrahepatic | 8(4.3) | 11(5.2) | .849 | 6(5.3) | 10(6.2) | .973 |
| Site of intrahepatic recurrence† | ||||||
| Local | 26(14.0) | 27(12.8) | .843 | 24(21.4) | 18(11.2) | .032 |
| Adjacent segment | 19(10.2) | 21(10.0) | 1.000 | 17(15.2) | 20(12.4) | .635 |
| Distal segment | 12(6.4) | 15(7.1) | .953 | 13(11.6) | 17(10.5) | .939 |
| Multisegment | 9 (4.8) | 10(4.7) | 1.000 | 11(9.8) | 18(11.1) | .873 |
| Recurrence | .280 | .024 | ||||
| 1-year recurrence rate, % | 29.6 | 25.4 | 38.4 | 31.9 | ||
| 3-year recurrence rate, % | 49.6 | 44.4 | 71.1 | 56.9 | ||
| 5-year recurrence rate, % | 54.4 | 49.8 | 76.4 | 62.9 | ||
†Calculated in patients with intrahepatic only and intra-plus extrahepatic recurrences. Bold values indicate statistical significance (P < .05).
Local recurrence, any recurrence located within 2 cm of the surgical margin, irrespective of any additional recurrence in other parts of the liver; adjacent segment recurrence, any recurrence located in the adjacent segment or in the same segment after subsegmentectomy, but with 2 cm away from the surgical margin; distal segment recurrence, any recurrence located not in the adjacent segment or in the contralateral hemiliver; multisegment recurrences, recurrences which involve multiple hepatic segments.