Table 4.
Candidate genes and genomic regions affecting multiple milk production traits in Holstein and its crossbreds.
| SNP name | Gene | Chromosome | Traits | Breed | Authors |
|---|---|---|---|---|---|
| rs41629125 | ITGB5 | 1 | MY, FY, and PY | Canadian Holstein | [25] |
| rs41631818 | MGC128242 | 1 | MY, FY, and PY | ||
| rs41587408 | PDZK1 | 3 | FP and PP | ||
| rs41578761 | LOC529633 | 7 | FY and PY | ||
| rs41662488 | LOC785678 | 9 | MY and PY | ||
| rs41569023 | ROCK2 | 11 | MY nad PY | ||
| rs41579049 | 5-OPase | 14 | FY and FP | ||
| rs41580517 | KCNQ3 | 14 | FY and FP | ||
| rs41587081 | ZFHX4 | 14 | MY and FP | ||
| rs41628862 | BIG1 | 14 | MY and PY | ||
| rs41633631 | TG | 14 | MY and FP | ||
| rs41570561 | SCARB1 | 17 | FP and PP | ||
| rs41581694 | FOXA3 | 18 | MY and PY | ||
| rs41585246 | SERPINA3-5 | 21 | MY and PY | ||
| rs41644615 | SERPINA5 | 21 | MY, FY, and PY | ||
| rs41640789 | POLR1C | 23 | FY and FP | ||
| rs41643632 | LOC534225 | 23 | MY and PY | ||
| rs43282015 | LOC614166 | 1 | MY and PY | Chinese Holstein | [21] |
| rs41663626 | LOC534011 | 3 | MY and PY | ||
| No rs | HAL | 5 | MY and PY | ||
| rs110727998 | GML | 14 | MY and FP | ||
| No rs | COL22A1 | 14 | MY and PY | ||
| rs109146371 | FOXH1 | 14 | MY, FY, and PP | ||
| rs109350371 | LOC786966 | 14 | MY, FY, PY, and PP | ||
| rs109421300 | DGAT1 | 14 | MY, FY, and PP | ||
| rs109752439 | C14H8orf33 | 14 | MY and PY | ||
| rs109968515 | CYHR1 | 14 | MY, FY, and PP | ||
| rs110017379 | NIBP | 14 | MY, PY, and FP | ||
| rs110060785 | GPIHBP1 | 14 | MY, PY, and FP | ||
| rs110199901 | ZNF66 | 14 | MY and FP | ||
| rs110622450 | COL22A1 | 14 | MY and FP | ||
| rs17870736 | VPS28 | 14 | MY, FY, and PP | ||
| rs41256919 | MAF1 | 14 | MY and FP | ||
| rs41629750 | GRINA | 14 | MY, FP, and PP | ||
| rs41583200 | C26H10orf84 | 26 | MY and PY | ||
| rs42462826 | FKBP2 | 1 | FY and PY | U.S. Holstein | [19] |
| rs109250591 | ITC14 | 1 | FY and PY | ||
| rs109703572 | 9 | MY and FY | |||
| rs43101493 | GNAS | 13 | MY, FY, and PY | ||
| rs41585412 | GNAS | 13 | MY, FY, and PY | ||
| rs41630667 | GNAS | 13 | MY, FY, and PY | ||
| rs111018678 | NIBP | 14 | FP and PP | ||
| rs42422883 | HHIP | 17 | FY and PY | ||
| rs108993234 | PGLYRPI | 18 | MY, FY, and PY | ||
| rs29010796 | MAF | 18 | FY and PY | ||
| rs109343058 | GPRI 10 | 23 | FY and PY | ||
| rs110886345 | 26 | FY, PY, and PP | |||
| rs110898125 | 26 | FP and PP | |||
| rs41626960 | MGMT | 26 | FY and PY | ||
| rs42227052 | FUT10 | 27 | MY, FY, and PY | ||
| rs41575183 | 27 | FY and PY | |||
| rs109335394 | X | FY and PY | |||
| rs41579345 | GLRA2 | X | FY and PY | ||
| rs41628209 | LOC616260 | X | FY and PY | ||
| rs41255709 | CXCR1 | 2 | MY, FY, and PY | Italian Holstein | [22] |
| rs29004485 | LEP | 4 | MY, FY, and PY | ||
| rs29004488 | LEP | 4 | MY, FY, and PY | ||
| rs109299401 | CSN3 | 6 | PY and PP | ||
| rs133669403 | PPARGC1A | 6 | MY and PY | ||
| rs43703011 | CSN2 | 6 | MY and PY | ||
| rs109625649 | LGB | 11 | MY and PY | ||
| rs110066229 | LGB | 11 | MY and PY | ||
| rs41255679 | LGB | 11 | MY and PY | ||
| No rs | CRH | 14 | PY and PP | ||
| rs109162116 | DGAT1 | 14 | MY, FY, PY, and FP | ||
| rs109234250 | DGAT1 | 14 | MY, FY, PY, FP, and PP | ||
| rs41580467 | TG | 14 | MY and FP | ||
| rs41758918 | TPH1 | 15 | MY and PY | ||
| rs42321611 | PRLR | 20 | MY, FY, PY, and PP | ||
| rs42714482 | THRSP | 29 | MY, FY, and PY | ||
| rs29017970 | LOC104973750 | 13 | MY and PY | Russian Holstein | [20] |
| rs41850250 | TRAFD1 | 17 | MY and PY | ||
| rs135514413 | ETS2 | 1 | FP and PP | Italian Holstein | [23] |
| rs41608610 | DGKG | 1 | MY, FP, and PP | ||
| rs109299401 | CSN2 | 6 | PY and PP | ||
| rs110981354 | CSN1S1 | 6 | FY, FP, and PP | ||
| rs133669403 | PPARGC1A | 6 | MY, FP, and PP | ||
| rs43703013 | CSN4 | 6 | MY and PP | ||
| rs43703015 | CSN4 | 6 | MY, FY, and PY | ||
| rs43706475 | CSN3 | 6 | MY and PY | ||
| rs110590698 | LPL | 8 | FY, FP, and PP | ||
| rs8193666 | TLR4 | 8 | MY, FP, and PP | ||
| rs110757796 | FABP4 | 14 | MY and PY | ||
| rs110937773 | FGF2 | 17 | MY and FY | ||
| rs109578101 | STAT5A | 19 | MY, PY, and FP | ||
| rs109686238 | CCL3 | 19 | FY and PY | ||
| rs109428015 | PRLR | 20 | FP and PP | ||
| rs41923484 | GHR | 20 | PY, FP, and PP | ||
| rs41257077 | PI | 21 | FY and PY | ||
| rs43765462 | LTF | 22 | FY and FP | ||
| rs43706495 | BTN1A1 | 23 | MY and FP | ||
| rs109913786 | AGPAT6 | 27 | FY and FP | ||
| rs381714237 | FCGR2B | 3 | MY, PY, and PP | US Holstein | [26] |
| rs110825637 | MGST1 | 5 | FY and FP | Chinese Holstein | [12] |
| rs137735153 | PLEKHA5 | 5 | FY and FP | ||
| rs109901151 | SLC4A4 | 6 | MY and PY | ||
| rs110694875 | ADAMTS3 | 6 | MY and PY | ||
| rs136639319 | TBC1D1 | 6 | FP and PP | ||
| rs137147462 | GC | 6 | MY and PY | ||
| rs378415122 | CENPE | 6 | MY, FY, and PY | ||
| rs385060942 | CENPE | 6 | MY, FY, and PY | ||
| rs453960300 | CENPE | 6 | MY, FY, and PY | ||
| ss2137349051 | CENPE | 6 | MY, FY, and PY | ||
| ss2137349053 | CENPE | 6 | MY, FY, and PY | ||
| rs377943075 | ACSBG2 | 7 | FY and PP | ||
| rs134985825 | RETSAT | 11 | MY, FY, PY, and PP | ||
| rs109146371 | PPP1R16A | 14 | MY, FY, PY, and PP | ||
| rs109350371 | PLEC | 14 | MY, FY, PY, and PP | ||
| rs109558046 | ARC-ADGRB1 | 14 | MY, FY, PY, and FP | ||
| rs110914335 | LY6H (d) | 14 | MY and PY | ||
| rs134444531 | NLK | 19 | PY and PP | ||
| rs41573457 | MRPS30 | 20 | MY and PP | ||
| ss2137349058 | MAP3K1 | 20 | MY, FY, and PY | ||
| rs41589462 | KCND3 | 3 | FP and PP | Chinese Holstein | [11] |
| rs136195618 | PROP1 | 7 | MY and PY | ||
| rs109350371 | PLEC | 14 | MY, PY, FP, and PP | ||
| rs109421300 | DGAT1 | 14 | MY, FP, and PP | ||
| rs109968515 | CYHR1 | 14 | FY and PY | ||
| rs110017379 | TRAPPC9 | 14 | MY, FP, and PP | ||
| rs41579243 | FAM135B | 14 | FP and PP | ||
| rs109646517 | MTMR3 | 17 | MY and PY | ||
| rs29014437 | SLC1A3 | 20 | MY and PP | ||
| rs41580312 | OSMR | 20 | MY and PP | ||
| rs41942492 | NIPBL | 20 | FP and PP | ||
| rs42340412 | ARID5B | 28 | FP and PP | ||
| rs109421300 | DGAT1 | 14 | FP and PP | Chinese Holstein | [14] |
| rs109007040 | VPS13B | 14 | MY, FP, and PP | French Holstein | [13] |
| rs109421300 | DGAT1 | 14 | MY and PY | ||
| rs41921161 | CCDC57 | 19 | FY and FP | ||
| rs110231369 | ARHGEF28 | 20 | FY and PY | ||
| rs385640152 | GHR | 20 | FP and PP | ||
| No rs | ADCK5 | 14 | MY, FY, FP, and PP | Chinese Holstein | [15] |
| No rs | FOXH1 | 14 | MY, FY, FP, and PP | ||
| No rs | GRINA | 14 | FY, FP, and PP | ||
| No rs | SLC52A2 | 14 | MY, FY, FP, and PP | ||
| rs109146371 | FOXH1 | 14 | MY, FY, FP, and PP | ||
| rs109752439 | C14H8orf33 | 14 | FY and FP | ||
| rs110323635 | MAPK15 | 14 | FY and FP | ||
| rs721532493 | PALLD | 8 | MY, FY, and PY | Korean Holsteins | [17] |
| rs109421300 | DGAT1 | 14 | MY, FY, PY, and PP | ||
| rs135549651 | SMPD5 | 14 | MY, FY, PY, and PP | ||
| rs207655744 | HSF1 | 14 | MY and FY | ||
| rs208640292 | HSF1 | 14 | MY and FY | ||
| rs209876151 | DGAT1 | 14 | MY and FY | ||
| rs211016627 | HSF1 | 14 | MY and FY | ||
| rs211223469 | DGAT1 | 14 | MY and FY | ||
| rs211282745 | HSF1 | 14 | MY and FY | ||
| rs384957047 | DGAT1 | 14 | MY and FY | ||
| rs380223715 | PKHD1 | 23 | MY and PY |