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. 2023 Jul 1;37(8):1626–1637. doi: 10.1038/s41375-023-01953-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A The absolute number of L-GMPs (GFP⁺CD34⁺CD16/32⁺) in BM of VC Phf6,RE9a and WT Phf6,RE9a AML mice. B. The percentage of L-GMPs in spleen of VC Phf6,RE9a and WT Phf6,RE9a AML mice. C Deletion of Phf6 decreased the self-renewal capacity of RE9a-expressing fetal liver cells in serial replanting assays. D The number of colonies generated from 3000 RE9a-expressing cells in third and fourth plating. E Kaplan–Meier survival curves of VC Phf6,RE9a and WT Phf6,RE9a mice in different dilutions of leukemia cells assay (log-rank test p < 0.05, n = 6 per group). F Loss of Phf6 significantly decreases the frequency of leukemia stem cells in the limiting dilution assay. The log-fraction plot (left panel) showed the results of the limiting dilution assay by using different dilutions of leukemia cells from VC Phf6,RE9a and WT Phf6,RE9a in vivo (right panel). Data are represented as mean ± SD.