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. 2023 Jul 10;26(8):1449–1460. doi: 10.1038/s41593-023-01359-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The DIAN-OBS comprises seven core centers, each working symbiotically to collect, analyze and prepare data for regular data releases. In the original grant cycle, these visits were completed every 3 years for asymptomatic participants and annually for symptomatic participants. After the DIAN grant cycle was renewed, the visit frequency was updated to be completed every 2 years for asymptomatic participants and annually for symptomatic participants. Given that most participants live large distances from the study sites, they typically travel to the location and complete all parts across 3 d. If1110.1038/s41593-023-01359-8participants live large distances from the study sites, they typically travel to the location and complete all parts across 3 d. If participants live in a study site city, they are able to complete the various components of the visit within 3 months. As the DIAN-OBS begins to implement tau-PET scans at applicable sites, these will be collected in place of the FDG-PET scans. Asymptomatic non-carriers stop in-person visits 5 years after they surpass their parental age of symptom onset. Figure created with BioRender.com.