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. 2023 Jan 7;45(3):1289–1302. doi: 10.1007/s11357-022-00721-1

Table 2.

AGRN/PRSS12 variants associated with sarcopenia phenotypes in UKBB and GenoFit cohorts

rsID Chr:position Ref/Alt AF Beta p value Phenotype Cohort N
AGRN
  rs2710873 1:1,042,813 G/A – 0.009 8.88 × 10−6 WBFFM UKBB 331,291
  rs2710873 1:1,042,813 G/A 0.179 0.026 0.019 WBLM GenoFit 6715
  rs2710873 1:1,042,813 G/A 0.179 0.024 0.019 ALM GenoFit 6715
  rs2710873 1:1,042,813 G/A 0.129  − 0.545 6.11 × 10−5 Plasma CAF GenoFit 260
PRSS12
  rs71608359 4:118,283,390 C/G – 0.015 8.35 × 10−6 Grip strength (right) UKBB 335,842
  rs71608359 4:118,283,390 C/G 0.089  − 0.042 0.014 Grip strength GenoFit 6715
  rs71608359 4:118,283,390 C/G 0.061  − 0.234 0.254 Plasma CAF GenoFit 260

Chr, chromosome; Ref/Alt, reference allele/alternative allele; AF, allele frequency (unknown AF for UKBB data); WBFFM, whole body fat-free mass; WBLM, whole body lean mass; ALM, appendicular lean mass; CAF, C-terminal agrin fragment; UKBB, UK Biobank