Table 4.

Single-variant analysis of AGRN/PRSS12 and sarcopenia phenotypes in the UKBB

Variant ID	Consequence	Ref/Alt	AF	Beta	p value	Phenotype
PRSS12
4:118,282,033	Missense	G/A	< 0.0001	− 4.06	2.27 × 10−9	Grip strength (right)
rs755244092	Missense	G/A	< 0.0001	− 4.03	2.95 × 10−9	Grip strength (right)
rs755244092	Missense	G/A	< 0.0001	− 3.79	2.34 × 10−8	Grip strength (left)
4:118,313,347	Missense	A/G	< 0.0001	− 2.52	2.33 × 10−5	WBFFM
AGRN
rs1644996826	Missense	G/A	< 0.0001	3.65	8.98 × 10−10	WBFFM
rs199563268	Missense	G/A	< 0.0001	− 1.02	2.19 × 10−5	Grip strength (right)
rs372918766	Missense	G/C	< 0.0001	− 2.78	4.34 × 10−5	Grip strength (right)
rs372918766	Missense	G/C	< 0.0001	− 3.32	1.03 × 10−6	Grip strength (left)

Ref/Alt, reference allele/alternative allele; AF, allele frequency; WBFFM, whole body fat-free mass