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. 2023 Aug 3;14:4659. doi: 10.1038/s41467-023-40310-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The Cox model included covariates of age, sex, education level, index of multiple deprivations, ethnicity, genotyping batch, and the first ten genetic principal components, in addition to a polygenic risk score and a multiplicative interaction term of the polygenic risk score with the stratification variable of interest. Each error bar is presented as lower and upper 95% confidence interval and no statistical correction is made for multiple comparisons across subgroups.