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. 2023 Aug 3;14(8):495. doi: 10.1038/s41419-023-06027-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Immunoblots of AOL, B7-H3, and AKT/MTOR pathway molecules in SW480 and HCT-8 cells treated with FDW028 or 2F-Fuc at 50 μM for 72 h. B Immunoblots of B7-H3 in SW480 and HCT-8 cells treated with FDW028 at the indicated concentrations for 72 h. C Immunoblots of B7-H3 in SW480 and HCT-8 cells after the treatment of FDW028 (50 μM) with or without following CHQ (50 μM) or AC (100 μM). D Immunofluorescence shows the colocalization of B7-H3 and LAMP1 upon the treatment of FDW028. The intensity profiles of B7-H3 and LAMP1 are plotted in the middle panel. The statistical results of colocalization factor (Pearson’s R value) are shown on the right panel. E Co-IP assays showed the effects of FDW028 on the interaction between B7-H3 and HSC70 or LAMP2A. F Immunoblots of B7-H3 in SW480 and HCT-8 cells treated by FDW028 (50 μM) with or without HSC70 siRNA for 72 h. G Immunoblots of B7-H3 in SW480 and HCT-8 cells treated by FDW028 (50 μM) with or without LAMP2A siRNA for 72 h. All experiments were performed in technical triplicates and are displayed as mean ± s.d.; ns no significance; *P < 0.05, **P < 0.01, ***P < 0.001.