TABLE 1.
Anti-HIV activities of T22, TW70, and T134 in MT-4 cellsa
| Compound | Sequenceb | CC50c (μg/ml) | EC50 (μg/ml) | SId |
|---|---|---|---|---|
| T22 | R-R-W-C-Y-R-K-C-Y-K-G-Y-C-Y-R-K-C-R-CONH2 | 49 | 0.076 | 645 |
| TW70 | R-R-W-C-Y-R-K-dK-P-Y-R-K-C-R-CONH2 | 40 | 0.030 | 1333 |
| T134 | R-R-W-C-Y-R-K-dK-P-Y-R-Ci-C-R-COOH | 305 | 0.009 | 33889 |
a
MT-4 cells were infected with HIV-1IIIB (multiplicity of infection, 0.01).
b
The substituted amino acids are underlined; deleted amino acids are double-underlined. Ci, l-citrulline.
c
CC50, 50% cytotoxic concentration.
d
SI, selectivity index based on the ratio of CC50 to EC50.