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Insensitivity of T134 to AMD3100-resistant virus
| Compound | EC50 (nM)a
|
||
|---|---|---|---|
| A018A | A031-1 | A031-2 | |
| T134 | 18.5 | 19.1 | 28.6 |
| AMD3100 | 49.0 | 1,000.0 | 1,330.0 |
| Zidovudine | 50.6 | 24.0 | 16.2 |
The EC50 was calculated on the basis of the reduction in the number of blue cells induced by wild-type HIV-1 (A018A) and AMD3100-resistant HIV-1 isolates (A031-1 and A031-2) in the MAGI assay.
