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. 2023 Aug 3;14:4666. doi: 10.1038/s41467-023-40416-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Overview of the 70S ribosome complexed with mRNA (cyan), tRNA^Phe in the aminoacyl (A) site (green), tRNA_i^fMet in the peptidyl (P) site (pink), tRNA^Phe in the exit (E) site (orange), and AMK bound to three potentially relevant sites. (Inset 1) AMK bound near the decoding center in the small subunit, (inset 2) AMK bound in the large subunit P site, and (inset 3) AMK bound at inter-subunit bridge B5. Chemical structures of the antibiotics AMK with the amino-hydroxy butyrate (AHB) moiety at the N¹ position of the central 2-deoxystreptamine (2-DOS) ring II (b), and KAN (c).