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. 2023 Aug 3;14:4666. doi: 10.1038/s41467-023-40416-5

Fig. 3. Amikacin binding site in the large subunit proximal to the P-site tRNA.

Fig. 3

a Cartoon representation of the 70S ribosome carrying three tRNAs with the AMK binding site indicated with the yellow star. b The unbiased (Fo – Fc) difference electron density map of AMK bound to the large subunit P site is contoured at 2.3σ. c In the large subunit AMK (yellow) binds near the CCA-end of the P-site tRNA (pink), the conserved 23S rRNA P-loop (white), and helix H93 (white). d Interactions between AMK (yellow) and the Watson-Crick base pair G2252-C74 formed by the P-loop (white) and the P-tRNA CCA-end (pink).