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. 2023 Jul 13;14:1224480. doi: 10.3389/fmicb.2023.1224480

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Copyright © 2023 De Pascalis, Bhargava, Espich, Wu, Gelhaus and Elkins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival outcomes of vaccinated rats after aerosol challenge with Ft demonstrated minimal differences between substrains. Fischer 344 rats were vaccinated as indicated. Six weeks after vaccination, rats were challenged by aerosol either with a high or low dose of Ft SchuS4. Survival was monitored for 21 days. The experiment included a total of 5 animals per vaccine-challenge dose group per substrain. For each challenge dose, bacterial lung deposition was monitored. The figure depicts time to death. Analyses of survival outcomes, calculated by Kaplan–Meier and log-rank (Mantel–Cox), indicated that differences between rat substrains were not significant. Whitin each challenge dose group, pairwise comparisons of LVS and ΔclpB by rat substrain showed no significant differences.