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. 2023 Mar 25;45(3):1817–1835. doi: 10.1007/s11357-023-00731-7

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Cross-validation analysis of three epigenetic clocks for centenarians. Age estimation 20-fold cross-validation (LOFO20) of the ENCen40 + , ENCen100 + , and NNCen40 + clocks in blood, saliva, and buccals cells, for different age ranges (columns). The panels relate chronological age (x-axis) to DNAm age estimates (y-axis) from the ENCen40 + (A, B, C) and NNCen40 + (D, E, F), and ENCen100 + (G, H, I), respectively. Each column corresponds to a different age range. DNA methylation data from age 40 to 115 (A, D, G), 100 to 115 (B, E, H), and 80 to 115 (C, F, I). Each panel reports the sample size (N), the median absolute error (MAE), Pearson correlation coefficient (r), the p value (p), and each point is color coded by sex (blue = male)