Table 3.
The pooled SMD (95% CIs) in meta-analysis for the association between potential SNPs and glycemic response.
| Variants | Study numbers | References | Sample size (AA/Aa/aa) | Effective marker | Comparison models | SMD | Model | P Q | I2 (%) | |
|---|---|---|---|---|---|---|---|---|---|---|
| SMD [95% CI] | P | |||||||||
| SLC22A1 rs628031 | 3 | (13) | 27/124/134 | ΔHbA1c% | AA vs. Aa | −0.26 (−0.68–0.16) | 0.229 | Fixed | 0.240 | 29.8 |
| (16) | 27/124/134 | ΔHbA1c% | Aa vs. aa | −0.45 (−0.70–−0.20) | 0.102 | Fixed | 0.333 | 9.0 | ||
| (17) | 27/124/134 | ΔHbA1c% | AA vs. aa | −0.13 (−0.55–0.30) | 0.556 | Random | 0.082 | 60.1 | ||
| SLC22A1 rs628031 | 3 | (13) | 27/124/134 | ΔFPG | AA vs. Aa | −0.22 (−0.64–0.20) | 0.308 | Fixed | 0.321 | 12.1 |
| (16) | 27/124/134 | ΔFPG | Aa vs. aa | −0.45 (−0.70–−0.20) | 0.000 | Random | 0.033 | 70.6 | ||
| (17) | 27/124/134 | ΔFPG | AA vs. aa | −0.60 (−1.04–−0.16) | 0.007 | Fixed | 0.347 | 5.6 | ||
| SLC22A1 rs622342 | 2 | (11) | 126/88/16 | ΔHbA1c% | AA vs. Aa | −0.45 (−0.73–−0.18) | 0.001 | Fixed | 0.742 | 0.0 |
| (12) | 126/88/16 | ΔHbA1c% | Aa vs. aa | 0.12 (−0.42–0.67) | 0.662 | Fixed | 0.829 | 0.0 | ||
| 126/88/16 | ΔHbA1c% | AA vs. aa | −0.32 (−0.84–−0.21) | 0.241 | Fixed | 0.886 | 0.0 | |||
| SLC22A1 rs1867351 | 2 | (26) | 180/121/46 | HbA1c% | AA vs. Aa | −0.18 (−0.42–0.06) | 0.143 | Fixed | 0.642 | 0.0 |
| (13) | 180/121/46 | HbA1c% | Aa vs. aa | 0.31 (−0.63–1.24) | 0.519 | Random | 0.034 | 77.7 | ||
| 180/121/46 | HbA1c% | AA vs. aa | 0.11 (−0.97–1.20) | 0.837 | Random | 0.014 | 83.6 | |||
| SLC22A1 rs2297374 | 2 | (26) | 121/150/77 | HbA1c% | AA vs. Aa | 0.05 (−0.20–0.31) | 0.666 | Fixed | 0.455 | 0.0 |
| (13) | 121/150/77 | HbA1c% | Aa vs. aa | −0.22 (−0.49–0.06) | 0.130 | Fixed | 0.409 | 0.0 | ||
| 121/150/77 | HbA1c% | AA vs. aa | −0.16 (−0.47–0.16) | 0.322 | Fixed | 0.167 | 47.5 | |||
| SLC22A1 rs594709 | 2 | (18) | 140/9 | ΔHbA1c% | (AA+ Aa) vs. AA | 0.16 (−0.51–0.84) | 0.633 | Fixed | 0.528 | 0.0 |
| (39) | 140/9 | ΔFPG | (AA+ Aa) vs. AA | 0.28 (−0.39–0.96) | 0.416 | Fixed | 0.400 | 0.0 | ||
| SLC22A2 rs316019 | 3 | (11, 14, 17) | 317/75/8 | ΔHbA1c% | AA vs. Aa | −1.15 (−2.47–0.17) | 0.088 | Random | 0.000 | 94.6 |
A, reference allele; a, alternative allele; OR, odd ratio; HbA1c%, glycated hemoglobin level; ΔHbA1c%, change in glycated hemoglobin level; ΔFPG, change in fasting plasma glucose level; SMD, standardized mean difference; 95% CI, 95% confidence interval; PQ value for Q-test; PZ value for Z-test.