TABLE 2.
Potential clinical applications for PNS + neurorehabilitation.
Diagnosis | Potential clinical application for PNS therapy | Physical exercise recommendations | Clinical readiness |
Parkinson’s disease | FES for tremor reduction (Meng et al., 2022) | FES combined with UE functional training (Popa and Taylor, 2015) |
Needs more research |
Stroke | Afferent PNS to median, radial, and ulnar nerves of paretic UE (Fleming et al., 2015) | PNS combined with repetitive task practice (Fleming et al., 2015; Kim et al., 2020) | Ready for implementation, more research needed for optimization |
TBI | Chronic TBI–FES for patients with hemiplegia (Ambrosini et al., 2011; Milosevic et al., 2021) Acute TBI–NMES for critically ill patients (Silva et al., 2019) |
Chronic TBI–FES combined with repetitive task practice (Lee et al., 2019) Acute TBI – NMES combined with functional sit < > stand training (Canning et al., 2003) |
Ready for implementation, more research needed for optimization |
SCI | FES for acute, chronic, incomplete and complete SCI (Mangold et al., 2005; Kapadia et al., 2011; van der Scheer et al., 2021) | FES combined with UE and/or LE cycling (van der Scheer et al., 2021) | Ready for implementation |