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. 2023 Jul 28;8(4):101575. doi: 10.1016/j.esmoop.2023.101575

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Schematic illustration of the role of sodium-¹⁸-fluoride (Na¹⁸F)-PET imaging in metastatic osteosarcoma. The fluoride ion (¹⁸F⁻) of Na¹⁸F is replacing one hydroxyl group (OH-) in the bone hydroxyapatite forming radioactive fluorapatite which can be imaged with a PET camera. Bone formation is present in soft-tissue metastases of osteosarcoma, and ¹⁸F-fluoroapatite in osteoblastic cells will be visualized using a PET camera. Thus Na¹⁸F-PET can be used for staging metastatic osteosarcoma because soft-tissue metastases become visible. PET, positron emission tomography.