Table 2.

The new NAFCIST criteria versus RECIST and PERCIST in primary bone tumors

	RECIST	PERCIST	NAFCIST
Characteristics	Anatomic response criteria for soft-tissue disease	Functional response criteria reflecting tumor glucose metabolism	Metabolic response criteria for bone-forming disease
Advantages	Commonly used	Response determination is possible regardless of the location	Response determination is possible regardless of the organ
Disadvantages	Limited to ‘measurable’ soft-tissue disease	Limited to FDG avid disease	Limited to NaF avid disease

FDG, [¹⁸F]2-fluoro-2-deoxy-D-glucose; NaF, sodium fluoride; NAFCIST, Na¹⁸F Response Criteria in Solid Tumors; PERCIST, Positron Emission Tomography Response Criteria in Solid Tumors.