TABLE 5.
Univariate and multivariate logistic analyses of cognitive impairment at 3 months after stroke.
| Univariate analysis | Multivariate analysis | ||||
| OR (95% CI) | p-value | OR (95% CI) | p-value | ||
| Population information | Gender (male) | 0.523 (0.384–0.712) | <0.001* | 0.672 (0.417–1.083) | 0.103 |
| Age | 1.053 (1.039–1.067) | <0.001* | 0.997 (0.974–1.020) | 0.792 | |
| Low level of education | 3.143 (2.227–4.436) | <0.001* | 2.075 (1.332–3.232) | 0.001 | |
| Stroke type | TIA | 0.348 (0.175–0.692) | 0.003* | 2.509 (0.816–7.715) | 0.109 |
| Cerebral infarction | 0.622 (0.340–1.137) | 0.123 | 2.858 (1.175–6.949) | 0.021 | |
| Lesion characteristics | Dominant hemisphere | 1.269 (0.964–1.670) | 0.089 | NA | |
| Large lesion | 0.777 (0.378–1.597) | 0.492 | NA | ||
| Brain-stem lesion | 0.934 (0.597–1.461) | 0.764 | NA | ||
| Critical sites lesion | 0.959 (0.654–1.407) | 0.832 | NA | ||
| Multiple lesions | 2.009 (1.480–2.727) | <0.001* | 0.831 (0.556–1.241) | 0.365 | |
| MTA score | 2.374 (2.007–2.807) | <0.001* | 1.348 (0.972–1.871) | 0.074 | |
| Fazekas score | 2.128 (1.87–2.410) | <0.001* | 1.585 (1.284–1.957) | <0.001 | |
| Microbleeds | 4.752 (3.190–7.080) | <0.001* | 1.043 (0.580–1.875) | 0.888 | |
| Risk factors | Hypertension | 1.016 (0.755–1.367) | 0.918 | NA | |
| Coronary heart disease | 1.342 (0.962–1.872) | 0.083 | NA | ||
| Diabetes | 1.015 (0.761–1.353) | 0.920 | NA | ||
| Drinking | 0.677 (0.519–0.884) | 0.004* | 0.982 (0.623–1.547) | 0.936 | |
| Smoking | 0.663 (0.508–0.866) | 0.003* | 0.832 (0.523–1.323) | 0.437 | |
| Laboratory examination | Hcy | 1.000 (0.990–1.011) | 0.944 | NA | |
| TG | 0.934 (0.837–1.043) | 0.224 | NA | ||
| TC | 0.993 (0.983–1.003) | 0.185 | NA | ||
| HDL | 2.107 (1.184–3.752) | 0.011* | 1.209 (0.756–1.933) | 0.428 | |
| LDL | 1.073 (0.914–1.259) | 0.388 | NA | ||
| Patients status at 3 months after stroke | Depression | 4.107 (2.250–7.498) | <0.001* | 2.243 (1.033–4.870) | 0.041 |
| mRS > 2 | 8.928 (4.651–16.949) | <0.001* | 3.154 (1.416–7.023) | 0.005 | |
| Low sleep quality | 3.052 (2.318–4.019) | <0.001* | 0.650 (0.410–1.031) | 0.067 | |
| Sleepiness | 2.011 (1.427–2.833) | <0.001* | 1.433 (0.792–2.594) | 0.234 | |
| Nocturnal TST (<7 h) | 8.214 (6.021–11.206) | <0.001* | 0.616 (0.294–1.291) | 0.199 | |
| Nocturnal TST (>8 h) | 5.157 (3.331–7.983) | <0.001* | 3.540 (1.692–7.406) | 0.001 | |
| High risk OSA | 2.508 (1.782–3.530) | <0.001* | 1.075 (0.666–1.733) | 0.768 | |
*p < 0.05, items with statistical significance in univariate analysis were included in the multivariate logistic regression analysis.