Table 1.
Demographic details of subjects. BMI – body mass index, PANSS – Positive and Negative Symptom Scale, SANS – Scale for Assessment of Negative Symptoms.
|
Schizophrenia patients (n = 18) (mean ± SEM) |
Controls (n = 19) | p-value | |
|---|---|---|---|
| Age (years) | 35.6 ± 2.1 | 37.84 ± 2.6 | 0.51 |
| Gender | 18/0 | 17/2 | 0.17 |
| Injected radioactivity (MBq) | 203.0 ± 8 | 196.9 ± 10 | 0.65 |
| Injected mass per body weight (µgm/kg) | 0.023 ± 0.001 | 0.024 ± 0.001 | 0.61 |
| BMI (kg/m2) | 30.0 ± 0.80 | 25.2 ± 0.93 | 0.001* |
| Mean age at onset (years) | 22.89 ± 1.2 | n/a | n/a |
| Mean duration of illness (years) | 11.7 ± 2.3 | n/a | n/a |
| PANSS Positive Negative General Total |
14.5 ± 0.5 21.4 ± 1.1 26.7 ± 0.8 62.6 ± 2.0 |
n/a | n/a |
| SANS-25 | 55.7 ± 5 | n/a | n/a |
| Revised social anhedonia scale | 17.4 ± 2.0 | 10.2 ± 1.8 | 0.009* |
| Revised physical anhedonia scale | 23.0 ± 2.9 | 13.7 ± 3 | 0.035* |
| Temporal experience pleasure scale Anticipatory pleasure scale Consummatory pleasure scale |
37.1 ± 2.4 28.0 ± 2.4 |
42.5 ± 2 34.8 ± 1.7 |
0.36 0.028* |
| Calgary depression scale total score | 8.5 ± 1.7 | n/a | n/a |
| Reaction time (s) Neutral trial Reward anticipation trial |
0.22 ± 0.01 0.21 ± 0.01 |
0.24 ± 0.01 0.23 ± 0.01 |
0.15 0.11 |
| Accuracy in reward anticipation (fraction of total trial) |
0.57 ± 0.05 |
0.6 ± 0.13 |
0.62 |