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. 2023 Jul 24;39:103481. doi: 10.1016/j.nicl.2023.103481

Table 2.

Associations between striatal activation during reward anticipation, striatal Mu Opioid Receptor (MOR) availability and measures of hedonic responses/symptoms. BPND – binding potential, PANSS – positive and negative symptoms scale, SANS – scale for the assessment of negative symptoms, TEPS – temporal experience of pleasure scale.

Measure
Striatal Reward > neutral anticipation parameter estimate
Striatal MOR BPND

SCZ
CTR
SCZ
CTR
r p r p r p r p
PANSS −0.196 0.43 n/a n/a −0.014 0.96 n/a n/a
PANSS-positive −0.172 0.50 n/a n/a 0.081 0.75 n/a n/a
PANSS-negative −0.120 0.63 n/a n/a −0.065 0.80 n/a n/a
PANSS-general −0.216 0.39 n/a n/a 0.008 0.97 n/a n/a
SANS-25 0.106 0.32 n/a n/a −0.166 0.51 n/a n/a
Revised social anhedonia −0.365 0.14 0.299 0.21 0.334 0.16 0.379 0.11
Revised physical anhedonia −0.231 0.36 0.281 0.24 0.197 0.43 0.281 0.24
TEPS anticipatory pleasure scale 0.383 0.12 −0.270 0.26 0.109 0.67 −0.451 0.05
TEPS consummatory pleasure scale 0.188 0.46 −0.244 0.31 0.246 0.33 −0.244 0.31
Reaction time (neutral) −0.254 0.34 −0.088 0.74 −0.215 0.42 −0.039 0.88
Reaction time (anticipation) −0.139 0.61 −0.286 0.27 −0.198 0.46 −0.284 0.27
Accuracy in reward anticipation −0.08 0.77 0.309 0.23 −0.102 0.71 −0.088 0.74