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. 2023 Jul 25;120(31):e2300191120. doi: 10.1073/pnas.2300191120

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Copyright © 2023 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 3. — 17β-estradiol rapidly decreases glutamatergic synapse number in CA1 pyramidal neurons in task-naïve mice. (A and B) GluA1 puncta density is unaffected by intradorsal hippocampal E2 or inhibitor [U0126 (A) and LY294002 (B)] treatment. (C and D) Bassoon puncta density is unaffected by intradorsal hippocampal E2 or inhibitor [U0126 (C) and LY294002 (D)] treatment. (E) E2 decreases glutamatergic synapse number (bassoon puncta positive for GluA1) in task-naïve mice. ERK pathway inhibition blocks this effect. (F) E2 decreases glutamatergic synapse number in task-naïve mice. LY294002 pathway inhibition does not block this effect. *P < 0.05, **P < 0.01. Data presented as mean ± SEM.