Figure 8.

A model depicting the role of PDGF‐BB in the CSDS‐induced depressive‐like behavior. Chronic chemogenetic inhibition of MS‐DG projection neurons induced the elevation of PDGF‐BB in SOM‐positive interneurons in the DG, which enhanced adult hippocampal neurogenesis via acting on PDGFRβ in the NSCs and alleviated CSDS‐induced depressive‐like behavior. On the contrary, activation of MS‐DG projection neurons induced depressive‐like behavior in the mice exposed to SSDS by decreasing the expression of PDGF‐BB in the DG, resulting in the impairment of adult hippocampal neurogenesis.