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. 2023 May 18;10(22):2300758. doi: 10.1002/advs.202300758

Figure 5.

Figure 5

Therapy of MPTP‐induced PD mice with biomimetic CSCCT NPs. a) Schematic illustration of MPTP‐induced PD mice, their therapy with CSCCT NPs and the course of behavior test. b) Rotatory‐rod test of mice from the Ctrl group, PD group, PD + Saline + US group, PD + CSCCT group, and PD + CSCCT + US group (n = 8). c) Morris water maze test from five groups of mice. Heat map of tracking path and parameter analyses showed changes in d) the swimming speed, e) the frequency through the target quadrant (n = 8), f) heat map of escape latency in successive five days. g) Open field test. Heat map of tracking path and parameter analyses showed changes in h) the mean speed, i) central zone transition number from five groups of mice (n = 8). j) Elevated plus‐maze (EPM) test. Heat map of tracking path and parameter analyses showed changes in k) the frequency of open arm entries from five groups of mice (n = 8). Data represented the mean ± SD (n = 8). The two‐sided one‐way ANOVA with a Tukey post hoc analysis was used for comparison among multiple groups. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns, not significant.