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. 2023 Jul 15;15(7):1119–1134. doi: 10.4251/wjgo.v15.i7.1119

Figure 2.

Figure 2

Programmed cell death 1 core fucosylation in tumorigenesis. Loss of core fucosylation catalyzed by fucosyltransferase 8 significantly enhanced CD8+ cytotoxic T cell activation and cytotoxicity by increasing programmed cell death 1 (PD-1) ubiquitination which in turn led to the degradation of PD-1 in the proteasome and more efficient. PD-1: Programmed cell death 1; PD-L1: Programmed cell death 1 ligand 1; Fut8: Fucosyltransferase 8; CTL: Cytotoxic T cell. This figure was summarized and modified from Zhang et al[33].